Chemobiological cues and Epigenetic controls
This Group will characterize chemical signals and gradients to which cells are exposed, such as proteins, exosomes and vesicles and their effects on cell functions. The data collected will generate the ability to create in vitro complex chemical environments, composed of precise molecule concentrations that will elucidate how biological processes are affected by biomolecules and their localised density. Specific attention will be addressed to the role of exosome, that are believed to be important for intercellular communication (i.e. neuronal and embryo-maternal communication, inter-embryo communication and pathogenesis) as well as possible markers for disease. A distinct interest of this Group will focus on the mechanisms defining cell fate, driving epigenetic restriction and leading to the acquisition of a distinct cell phenotype.